*the major flavonoid components of euphorbia prostrata extract are apigenin, luteolin, apigenin-7-glucoside and luteolin-7-glucoside. the major phenolic compounds present are gallic acid, ellagic acid and tannins.
*anti-hemorrhoidal activity : euphorbia prostrata extract has been clearly shown to have significant anti-hemorrhoidal activity as demonstrated by ano-rectal body: weight ratio model in rats.
*anti-inflammatory activity : various components of euphorbia prostrata extract are known to affect inflammatory response to antigen. apigenin-7-glucoside inhibits release of histamine, generation of hydrogen peroxide and leucocyte infiltration at inflammatory site. luteolin-7-glucoside decreases leucocyte infiltration.
*haemostatic activity : euphorbia prostrata extract on topical application significantly reduced the bleeding time. this effect could play an important role in arrest of bleeding. wound healing effect : topical application of euphorbia prostrata extract has been shown to have significant wound healing effect.
*vasoprotective activity : flavonoids tend to decrease capillary permeability and increase capillary resistance. several mechanisms have been proposed such as inhibition of ascorbic acid oxidation, blood cell aggregation and stimulation of pituitary-adrenal axis.
*sclerosing activity : tannins present in euphorbia prostrata extract cause sclerosis of the mucus membrane by virtue of their protein precipitating property.
*anti-oxidant activity : flavonoids and phenolic compounds of the extract have anti-oxidant property which also contributes in healing of inflammatory tissue damage in hemorrhoidal conditions.
*not recommended in children, during pregnancy and breast feeding, if allergic to any of the ingredients and in patients on anticoagulant therapy
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